Is it possible to safely insert a USB into your main computer and prevent any malware from automatically running?

Apparently a common tactic to gain entrance into an organizations computer systems is to install some malware onto a USB and to simply throw the USB stick on the ground infront of someone's office. Invariably someone will pick it up and insert it into their computer out of curiosity or a desire to snoop on someone. The malware on the USB somehow automatically infects the computer when you insert the USB.

Is it possible to insert a USB into your …

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